Severe, existence-threatening, or deadly respiratory melancholy is described with the use of opioids, such as codeine, one of the active components in Promethazine HCl and Codeine Phosphate Oral Solution. Codeine generates dose-linked respiratory melancholy by directly acting to the Mind stem respiratory center that controls respiratory rhythm and will make irregular and periodic respiration. Codeine is matter to variability in metabolism centered upon CYP2D6 genotype, which may result in an elevated exposure into the Lively metabolite morphine [see Warnings and Precautions (5.3)]. Promethazine exerts a depressant impact on the respiratory Heart which is independent of and additive to that of other respiratory depressants, including codeine [see Warnings and Safeguards (five.

Promethazine HCl Oral Answer is contraindicated in comatose states, As well as in individuals identified to become hypersensitive or to possess had an idiosyncratic reaction to promethazine or to other phenothiazines.

Antihistamines and codeine are both of those contraindicated to be used within the treatment of decreased respiratory tract indicators, which includes asthma.

A household teaspoon isn't an accurate measuring gadget and could lead to overdosage, especially when fifty percent a teaspoon is usually to be measured. It really is strongly recommended that an accurate measuring device be made use of. A pharmacist can offer an proper unit and can provide instructions for measuring the correct dose.

Do not take any benzodiazepines or medicines that may cause drowsiness or sleepiness throughout therapy with Promethazine Hydrochloride and Codeine Phosphate Oral Answer. Inquire your Health care service provider for a list of these medicines if You aren't absolutely sure.

, ritonavir) or discontinuation of a cytochrome P450 3A4 inducer which include rifampin, carbamazepine, and phenytoin, could cause an increase in codeine plasma concentrations with subsequently increased metabolism by cytochrome P450 2D6, causing greater morphine ranges, which could raise or extend adverse reactions and may result in probably fatal respiratory despair.

On account of identical pharmacologic properties, it's realistic to be expecting identical risk with concomitant use of opioid cough medications and benzodiazepines, other CNS depressants, or alcohol.

Symptoms and signs or symptoms of overdosage with promethazine HCl vary from gentle depression of the central anxious process and cardiovascular technique to profound hypotension, respiratory depression, unconsciousness, and unexpected Demise.

Promethazine is contraindicated in comatose states, As well as in persons regarded to generally be hypersensitive or to get had an idiosyncratic reaction to promethazine or to other

Promethazine: Signs and indicators of overdosage with promethazine HCl range from moderate melancholy on the central nervous system and cardiovascular system to profound hypotension,

A pharmacist can recommend an acceptable measuring device and click here can provide Recommendations for measuring the correct dose.

Stimulation might be evident, specifically in small children and geriatric people. Convulsions may perhaps almost never come about. A paradoxical-form reaction is noted in kids acquiring one doses of 75 mg to 125 mg orally, characterised by hyperexcitability and nightmares.

Human Facts Posted information from situation-Management and observational experiments on codeine use throughout pregnancy are inconsistent within their results. Some reports of codeine publicity showed a heightened chance of Over-all congenital malformations while some didn't.

Many scientific studies analyzing the use of promethazine in pregnancy did not come across an Affiliation with a heightened danger of congenital anomalies. While in the few reports reporting an association, no reliable sample of malformations was pointed out.